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control subjects, matched with the cancer patients as for
history of non-neoplastic diseases of the upper airways
(mainly chronic rhinosinusitis and asthma), age and sex
were selected as well and involved in the study. Both the
cases and the controls underwent nose endoscopy, nose
cytology, rhinomanometry, olfactometry and saccharin
test for mucociliary clearance. Differences between cases
and controls were evaluated for each parameter.
Statistical analysis was performed using the JMP software
version 7.0.1 (SAS Institute).
Results
No significant differences between cases and controls for
any of the functions evaluated were detected.
Conclusion
Squamous cell carcinoma of the nasal vestibulum is a
tricky situation for the clinician, as it is often a treatable
disease but may harbor significant long term sequelae. On
one hand, when planning surgical treatment of these
lesions, while obtaining a resection with clear margins is
usually quite easy, the achievement of a satisfying
aesthetical restoration appears often almost impossible.
On the other hand, also external beam radiotherapy is
associated to well-known late toxicities: in particular
notable alteration in nose cytology and mucociliary
clearance, and chronic crusting are associated to the
exposure of nose mucosa to EBRT.
The present work demonstrates that brachytherapy has
the advantage of preserving the main nose functions with
relevant implication for the quality of life of surviving
patients.
EP-1793 High-dose-rate brachytherapy for lip and oral
cavity tumors
C. De la Pinta
1
, T. Muñoz
1
, A. Montero
2
, J. Dominguez
1
1
Hospital Ramon y Cajal, Radiation Oncology, Madrid,
Spain
2
Grupo Hospital Madrid, Madrid, Spain
Purpose or Objective
The aim of this study was to evaluate the clinical and
cosmetic outcomes and recurrence-free and overall
survival in patients treated with high-dose-rate
brachytherapy for lip and oral cavity tumors.
Material and Methods
All patients referred for interstitial high-dose-rate
brachytherapy in our centre from 2007 to 2016 with
histologically confirmed squamous cell carcinoma (17p)
and basaloid carcinoma (2p) of the lip or oral cavity were
retrospectively analysed. Tumor sites included the lips
(15p), mouth (3p) and gingiva (1p). Treatment consisted
of brachytherapy alone (11p) or recurrence or adjuvant
after surgery (8p). All patients were treated with
interstitial brachytherapy median implant dose 51 Gy
(range 50- 60Gy).
Inclusion criteria were as follows: head and neck location
and malignant tumors.
Results
With a median follow-up of 55 months (range 3-246
months), local control was achieved on clinical
examination or CT scan.
Acute toxicities (11/19p) consisted of ephitelitis grade 1
(3p), grade 2 (4p) and grade 3 (4p). Not acute toxicity
grade 4 was
reported.
Late toxicities (9/19p) were hypopigmentation and
fibrosis. One patient had
necrosis.
Among 19 patients studied, 2 lost follow-up and they were
excluded from the survival analysis.
Preservation of organ functions was in all patients.
Using Kaplan-Meier analysis overall survival after minimum
follow-up of 55 months was 94,1% and disease-free
survival was 89,4%. One patient had a locoregional
recurrence and died of tumor.
Conclusion
Interstitial brachytherapy is a good choice to deliver high-
dose radiation in lip and oral cavity tumor after surgery or
as an exclusive treatment. This treatment offers adequate
locoregional control with acceptable range of
complications.
Electronic Poster: Brachytherapy: Physics
EP-1794 Intra-op check of ONCURA Rapid Strand
(Model 7000) seeds radioactivity in LDR prostate
brachytherapy
V. Stserbakov
1
, K. Aru
2
1
North-Estonian Regional Hospital Cancer Center
Radiotherapy, Department of Radiotherapy and
Oncology, Tallinn, Estonia
2
North-Estonia Medical Centre- Cancer Center,
Department of Radiotherapy and Oncology, Tallinn,
Estonia
Purpose or Objective
To introduce into clinical practice procedure for checking
the radioactivity of Oncura rapid strand seeds for LDR
prostate brachytherapy deriving the expected value for
the strand activity from measurement of activity for each
single seed. To perform measurement in possibly more
clean radiation safety conditions with minimal exposure
dose to personal by optimizing every step of the
procedure.
Material and Methods
For measurement the radioactivity of ONCURA single seed,
cut off from the strand, it was used well-chamber HDR
1000 Plus (calibration factor for I-125(9011) 2,388 E11
µGy·m
2
/h/A of Standard Imaging) with special insertion
for seed. CHARGE mode of Unidos (PTW-Freiburg)
electrometer was LOW (≤230 pC). Collected time was 1
min. Setting-up for measurement of the radioactivity of
rapid strand (containing 4/5/6 seeds) is shown in the
figure (a). The well-chamber (7) was placed into plastic
container (5), which one then was covered by sterile
coating (4) in order to keep external sterile conditions.
Plastic container, as well, prevents of not needed external
contacts with well-chamber, since its electrometer is
working in most sensitive mode. Tweezers (2) with rapid
strand (6) and short transport container (1) was mounted
into sterile cylindrical tube (barrel) of BBraun Oroginal-
Perfusor Syringe® 50 ml (3), which was used as holder for
inserting into well-chamber cavity. Devices for performing
radiation safely operating with strands are shown on figure
(c,
d).