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• Large deformations of resection

specimen make 3D correlation with

pre-operative imaging is very difficult

• Lung lobes were inflated with

formalin to approximate the CT

volume

• Registration in two steps:

1. find correct orientation of CT with

sliced specimen; resample CT in the

same plane

2. match macroscopic slices to CT

volume

• Verify GTV volume and shape

• Identify the extent of the CTV

Stroom et al. 2007; Int J Radiat

Oncol Biol Phys. 69:267-275

3D validation of contouring with pathology