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0

0.5

1

1.5

2

2.5

3

0

0.5

1

1.5

2

2.5

3

Tumor Amplitude [cm]

Margin [cm]

Mean + Bone

ITV + Bone

ITV + Tumour

Mean + Tumour

σ

σ

σ

σ

7.0 5.2

84.0 )

( 84.0 5.2

2

2

2

+Σ ≠

− +

+Σ =

p

p

M

σ

p

6.4 mm

Assures 80% isodose encompasses GTV 90% of time in lung

Margins versus amplitude