0
0.5
1
1.5
2
2.5
3
0
0.5
1
1.5
2
2.5
3
Tumor Amplitude [cm]
Margin [cm]
Mean + Bone
ITV + Bone
ITV + Tumour
Mean + Tumour
σ
σ
σ
σ
7.0 5.2
84.0 )
( 84.0 5.2
2
2
2
+Σ ≠
− +
+Σ =
p
p
M
σ
p
≈
6.4 mm
Assures 80% isodose encompasses GTV 90% of time in lung
Margins versus amplitude