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DCE Analysis
−
=
e
t
p
trans
t
v
C C K
dt
dC
td
v
t t
K
tC K tC
e
trans
t
p
trans
t
′
′−
−
′
=
∫
)
(
exp )(
)(
0
Ck
T T
1
10
1
1 1
+ =
)
exp(
cos 1
)
exp(
1
sin
1
1
TTR
TTR
M SI
−
−
− −
=
α
α
C
p
C
t
v
e
Analysis Method:
1. Determine pre-contrast T
10
(e.g. Multiple flip angles & (1) )
2. Determine T
1
during DCE from (1) and T
10
3. Estimate C
t
from (2); C
p
empirically
4. Substitute C
t
and C
p
to find K
trans
from (3)
(1)
(2)
(3)