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3 weeks

MRI

P

atient

inclusion

staging

Patient follow-up - 2 years: clinical/CT

Remission

continue follow-up

Lesion progression

biopsy (+)

treatment

biopsy (-)

continue follow-up

Correlation imaging-outcome

2 years endpoint

Start

CRT

End

CRT

Baseline

MRI

Lesion

Identification

Routine imaging

3 Months CT