614 / 1116
•
23 pts dose level I (5.7 Gy), 18 pts dose level II (14.2 Gy) in first 10 fractions.
•
2 cases of DLT at dose level I (grade 4 dermitis & dysphagia).
•
1 toxic death at dose level II (not RT-related?).
•
In 4 of 9 relapsed patients, the site of relapse was in the PTV-PET.
•
PET-guided dose escalation appears to be well-tolerated?
UZ Gent Phase I trial
Madani I. et al. Int J Radiat Oncol Biol Phys 2007.
Duprez F. et al. Int J Radiat Oncol Biol Phys 2011.