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All reported results for DWI & response assessment

Dirix P. et al. Seminars in Radiation Oncology 2014.

Study

n

During

CRT

After

CRT

Correlation

Results

Kim et al.

Clin Cancer Res 2009

33 1w

2w

Response

after CRT

Baseline ADC of responders was significantly lower.

A significant increase in ADC was observed in responders

within 1 week of CRT which remained until after CRT.

Galban et al.

Transl Oncol 2009

15 3w

-

6-month LC

Significant differences in ADC were observed between

patients with different outcomes.

Vandecaveye et al.

Eur Radiol 2010

30 2w & 4w

-

2-year LRC

The ΔADC 2 and 4 weeks after the start of CRT was

significantly lower in lesions with recurrence.

King et al.

Eur Radiol 2010

50 2w

6w

2-year LRC

A significant correlation was found between local failure and

post-treatment ADC but not pre- or intra-treatment ADC.

Hatakenaka et al.

IJROBP 2011

38 -

-

2-year LC

Baseline ADC of responders was significantly lower.

Vandecaveye et al.

IJROBP 2012

29 -

3w

2-year LRC

The ∆ADC of lesions with later recurrence was significantly

lower.

Srinivasan et al.

JCAT 2012

17 -

-

2-year outcome Baseline ADC of responders was significantly lower.

King et al.

Radiology 2013

30 2w

-

2-year LC

Baseline ADC showed no correlation with local failure.

During treatment, primary tumors showed a significantly

lower ∆ADC for local failure.