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Direct Dose at Tumour Cell Foci
Cell density (or proliferation rate) is spatially variable:
∑
=
−
=
N
i
i
i
D
N
F
1
)
exp(
1
α
ρ
) (
i
x
ρ
Both concepts may redistribute dose in the target volume,
i.e.
reduce the dose in some parts
to gain the possibility
to increase it in others
.
Alternatively, define one or multiple nested functional
PTVs.
requires a formula that relates
image intensity to .
) (
i
x
ρ