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Systemic therapy
•
Most studies of chemotherapy are retrospective, and no
d i d di h b
f
d
ran om ze stu es ave een per orme
•
Response rates for induction therapy with e.g. cisplatin and 5‐
FU of up to 70%
•
The effect of chemotherapy on locoregional control, distant
metastases and survival is still unresolved (except SNUC and
,
SNEC)
•
Systemic therapy during RT should be used with caution –
unexpected toxicity and complications may occur when
intensive multimodality regimens are used in this anatomical
area
•
Studies on the effect of other systemic therapies as
antibodies, tyrosine kinase inhibitors, and radiosensitizers are
ongoing and results awaited