2070-2071 / 2351
R
Platinum-5FU
Platinum-5FU + cetuximab Cetuximab monotherapy
6 chemotherapy cycles until PD or toxicity
Primary endpoint: survival
N= 442
EXTREME Trial: first line palliative treatment
Platin/5-FU vs platin/5-FU plus cetuximab
Vermorken et al, NEJM, 2008