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evade and suppress the immune system
MHC = major histocompatibility complex; TGF-ß = tumor growth factor-ß.
Drake CG, et al.
Adv Immunol.
2006;90:51–81; Vesely MD, et al.
Annu Rev Immunol
. 2011;29:235–271.
Inhibition of tumor antigen presentation
e.g. down regulation of MHC I
1
APC
Inhibition of attack by
immune cells
e.g. through T-cell
checkpoint pathways
3
Inactive
T cell
Secretion of
immunosuppressive factors
e.g. TGF-ß
2
Tumor
cell
Recruitment of
immunosuppressive cell types
e.g. T-reg
4
Activated
T cell