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Accuracy after (chemo)radiation for head and neck carcinoma:
Local
Sensitivity
Specificity
PET
50% - 100%
64% - 93%
Regional
Sensitivity
Specificity
PET
40% - 100%
25% - 100%
FDG-PET
Problems:
•
<3-4 months after (C)RT high incidence equivocal and
inaccurate interpretation (local and regional)
•
Problems:
•
False-positive: inflammatory effect
•
False-negative: tumors < 0.5 cm
Negative predictive value at 3 months in general very reliable
Salvage Surgery