2302-2303 / 2351
Low-risk UP patients for potential treatment de-escalation
p16-positive status
Dixon et al, Head Neck (2016)
Can
HPV positivity or overexpression of p16
be used as
surrogate markers guiding the localization of the primary
tumor???
1. etiological association
2. ICH staining for HPV in every biopsy
Fotopoulos et al, Oral Oncology (2015)
…HPV is a probable causative agent
UP is a distinct pathologic entity,
similar to oropharyngeal and nasopharyngeal virus-related malignancy carcinoma
,
particularly when in the presence of a bulky IIA node in which high-risk HPV/EBV detection is 70%
Associated with
younger age
,
nonsmoker status
, and
lower disease burden at presentation
Bussu et al, Ann Surg Oncol (2015)
HPV AND NECK METASTASIS FROM UNKNOWN PRIMARY
mercoledì 29 giugno 16