462-463 / 2351
RT + EGFR inhibition synergies
/
Ionizing radiation
G2 M‐block
EGFr‐I
G1‐ block
• EGFr‐I induces apoptosis
(~ 2 fold)
• RT induces apoptosis
(6 Gy – 2 fold)
• RT and EGFr‐I synergistic effect
(5‐6 fold)
Huang SM Cancer Res 1999; Harari PM IJROBP 2001;
Nyati MK Clin Cancer Res 2004