VG H&N course intro Florence 2016.pptx

RTOG 1016 de‐escalation study

p16+ oropharyngeal carcinomas

T1‐2,N2a‐3 or T3‐4 any N

RT 70Gy/35f/6 wks + cisplatin 100mg/m² x 2

Stratify:

T 1‐2

ANDOMI

T3‐4

N0‐2a

N2b‐c

Closed 2013 after 987 patients accrued

>10 PY>

Zubrod 1‐2

RT 70Gy/35f/6 wks + cetuximab for 8 weeks