650-651 / 2351
Summary – key points
•
Modified fractionation (hyperfractionation and/or
acceleration) is superior to conventional fractionation
•
Hypoxic sensitizers (e.g. nimorazole) improves tumor control
and survival without enhancing radiation morbidity
•
Concomitant platinum-based chemotherapy is more effective
than RT alone for younger patients in good performance
status with and advanced stage tumours. Acute and late
toxicity is increased
•
EGFR inhibition combined with radiotherapy (but not
chemoRT) results in enhancement of tumor response
•
The optimal combination of these ’radiotherapy intensifiers’ is
still unsettled