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Legionellales, obligate intracellular parasite
G
ti
ith LPS Ph I d Ph II
Baca
et al.
1984
Background
ram nega ve w
: ase an ase
Metabolically active axenically, esp. at lower pH
Life cycle: LCV and SCV
Acute (>50% seroconvert-asymptomatic) and chronic infectious
disease
Broad zoonotic reservoir; high seropositivity rate
Replicates in a “remodeled” phagolysosome-like vacoule
G i
di ti
*
2150 ORF
enom c pre c ons : ~
s
Complete TCA, various aa auxotrophs
Large group of transporters
Proteomic skew to high pI
Complete Type 4 secretion element
>200 genes with single/point mutation “pseudogene”
*Seshadri
et al.
PNAS 2003
Background
*
15 JANUARY 2010 VOL 327 SCIENCE
Hundreds of Q fever cases reported during Operation Iraqi Freedom
and Afghanistan war