Microsoft PowerPoint - L00 Introduction

Factors to consider 2

The type and quality of surgery are major

(non-randomized) prognostic factors

Poor compliance may compromise the

activity of adjuvant chemotherapy

After preoperative chemoradiation and

surgery, time to start adjuvant

chemotherapy is probably too long

Any benefit from 5FU may be achieved by the

preop 5FU ie pCR