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SCC of the Anal Margin : Prognostic Factors
•
Anal margin tumours have been reported to have both a better and worse
prognosis than anal canal lesions – ACT 1 trial found no effect for LRF or OS.
•
Studies of prognostic factors specific to anal margin tumours are lacking and
reported series are small
Chapet et al ( 2007 ) - 26 patients treated with primary EBRT or adjuvant RT
after local excision : cancer specific survival related to age, tumour
differentiation, T stage & N stage
Khanfir et al ( 2008 ) – 45 patients with primary EBRT or adjuvant RT after
local excision : no factors ( T stage, N stage, histological grade or age ) were
predictive of loco-regional control
Tumour diffn 5 yr CSS
Well diffn 85 %
Mod diffn 67 %
Poor diffn 50 %
T stage 5 yr CSS
T1
100 %
T2
92 %
T3
37 %
T4
0 %
N stage 5 yr CSS
N0
93 %
N1
67 %
N2
33 %