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The Royal Marsden
1958 – to present
•
Jass (St Marks, UK) : increasing depth of spread – independent prognostic
significance
•
Harrison (Tennessee, USA): prognostic score use depth of spread in mm
•
Cawthorne (Guildford, UK): depth of spread significance
•
Merkel and Hermanek (Erlangen, Germany) :
T3 subclassification
• T3a <1mm
• T3b>1-5mm,
• T3c>5-15mm
• T3d>15mm (TNM staging system 1993 supplement)
Extramural depth of spread is an equally important prognostic factor as node status