397 / 1068
The Royal Marsden
EXPERT C trial for patients at high risk
of local and distant failure
– Tumors within 1 mm of mesorectal fascia
(ie, potential circumferential resection
margin involvement)
– T3 c (extramural spread 5-15 mm) and
T3 d (extramural spread >15 mm),
regardless of N stage
– MRI T4a or T4b disease regardless of N
stage
– Low rectal cancer with tumor bordering
the intersphincteric/ distal TME plane on
MRI
– Tumors with MRI extramural venous
invasion (mrEMVI)