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pCR after CRT for LARC – Evidence for a Better
Outcome.
•
Maas et al ( 2010 ) : pooled analysis of 3105 patients undergoing
surgery after CRT for LARC ( 17 datasets ; 27 published articles )
pCR
– 484/3105:
16 %
median follow-up :
48 months
( 0 – 277 )
5 yr crude DFS : pCR
83.3 %
non-pCR
65.6 %
•
Adjusted HRs after multivariate analysis:
DFS
0.54
( 0.4 – 0.73 )
Local recurrence
0.41
( 0.21 – 0.81 )
Distant metastasis free survival
0.49
( 0.34 – 0.71 )
OS
0.65
( 0.47 – 0.89 )