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Locally advanced Rectal Cancer (LARC) 2:
•
However, only 10-25% achieve a pathological CR or
CCR after definitive CRT
•
Approx 30-40% of patients fail to respond
•
Most patients will not achieve sustained local
control unless surgery is added.
•
Despite low dose - considerable late morbidity
•
Late morbidity is contributed to (but not usually
caused) by surgery.