Hyperfractionation
RTOG 00-12
hyperfractionated CRT did not improve
the rate of pathologic complete response
or any clinical outcome (LC, DFS, OS)
Mohiuddin M,
et al.
Neoadjuvant chemoradiation for distal rectal cancer: 5-year updated results of a randomized phase
2 study of neoadjuvant combined modality chemoradiation for distal rectal cancer. Int J Radiat Oncol Biol Phys 2013:
86:523–528