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Acute SB Toxicity: pathogenesis
DAMAGE
ADSORPTION
Distortion of the villous
enzymatic
deficit decreased capability to digest
macromolecules in the intestinal lumen
Accumulation of
glucides e peptons
retains osmotically fluids
in the bowel lumen.
Osmotic DIARRHEA
SYMPTOMS
Increase of
organic residues
with
ph reduction
reduced
adsorbtion of electrolites, gas production, endotoxin
secretion.
METHEORISM, CRAMPS, PAIN
Increase of the intraluminal fats
decreased absorption of
biliary salts Direct mucolytic action, increased cellular
permeability and sodium trasudation
Hyperperistaltism Reduction of the transit time
Increased pathogenic bacterial.
Aqueous DIARRHEA
loss of appetite, weight loss, electrolyte imbalance…