791 / 1068
5
EORTC 22861
XRT
XRT + 5 FU-MMC p value
Complete response
54%
80%
Local Failure rate (5 years) 50%
32%
0,02
Colostomy free survival
Increase by 32% (see graph)
0,03
DFS (5 years)
Estimated improvement by 18%
OS
54%
58%
0,17
Colostomy-free survival
ACT-I
• RT
45Gy/20-25 fractions
• CRT
(5FU 2 x 4d. Mito 12 mg/m)
After 6 weeks boost:
• Irdidium implant to 25Gy (10Gy/d.)
or
• External beam irradiation: 15Gy in 6 fractions
Northover, Br J Cancer 2010