859 / 1068
Conclusions
1. 5FU-based CRT (45-50Gy) more effective
(downsizing) than RT but no improvement
in SpS, DFS or OS
2. Capecitabine is an equivalent option
3. Watch and wait remains experimental
4. Radio-sensitizing 5FU-based CRT not
improved by additional oxaliplatin ?
5. Biologicals have not yet delivered
6. Postop adjuvant chemotherapy after SCPRT
or CRT remains of unproven benefit