NCCN VERSION 2 2015

NCCN Guidelines Index

Breast Cancer Table of Contents

Discussion

and this illustration may not be reproduced in any form without the express written permission of NCCN

Note: All recommendations are category 2A unless otherwise indicated.

Clinical Trials: NCCN believes that the best management of any cancer patient is in a clinical trial. Participation in clinical trials is especially encouraged.

BINV-L

NCCN Guidelines Version 2.2015

Invasive Breast Cancer

DEFINITION OF MENOPAUSE

Clinical trials in breast cancer have utilized a variety of definitions of menopause. Menopause is generally the permanent cessation of menses,

and as the term is utilized in breast cancer management includes a profound and permanent decrease in ovarian estrogen synthesis. Reasonable

criteria for determining menopause include any of the following:

• Prior bilateral oophorectomy

• Age ≥60 y

• Age <60 y and amenorrheic for 12 or more months in the absence of chemotherapy, tamoxifen, toremifene, or ovarian suppression and

follicle-stimulating hormone (FSH) and estradiol in the postmenopausal range

• If taking tamoxifen or toremifene, and age <60 y, then FSH and plasma estradiol level in postmenopausal ranges

It is not possible to assign menopausal status to women who are receiving an LHRH agonist or antagonist. In women premenopausal at the

beginning of adjuvant chemotherapy, amenorrhea is not a reliable indicator of menopausal status as ovarian function may still be intact or

resume despite anovulation/amenorrhea after chemotherapy. For these women with therapy-induced amenorrhea, oophorectomy or serial

measurement of FSH and/or estradiol are needed to ensure postmenopausal status if the use of aromatase inhibitors is considered as a

component of endocrine therapy.