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NCCN Guidelines Index
Breast Cancer Table of Contents
Discussion
Version2.2015, 03/11/2015© National Comprehensive Cancer Network, Inc. 2015,All rights reserved.The NCCN Guidelines
®
and this illustration may not be reproduced in any form without the express written permission of NCCN
®
.
Note: All recommendations are category 2A unless otherwise indicated.
Clinical Trials: NCCN believes that the best management of any cancer patient is in a clinical trial. Participation in clinical trials is especially encouraged.
IBC-2
NCCN Guidelines Version 2.2015
Inflammatory Breast Cancer
k
Patients with stage IV or recurrent IBC should be treated according to the guideline for recurrence/stage IV disease (
BINV-17
to BINV-22).
l
See Principles of Breast Reconstruction Following Surgery (BINV-H)
.
m
See Chemotherapy Regimens for Recurrent or Metastatic Breast Cancer (BINV-N)
.
n
See Principles of Radiation Therapy (BINV-I)
.
TREATMENT
k
Response
No
response
Total mastectomy + level l/ll axillary dissection +
radiation therapy to chest wall and supraclavicular
nodes (plus internal mammary nodes if involved,
consider internal mammary nodes if not clinically
involved [category 3]) ± delayed breast
reconstruction
l
Consider additional systemic
chemotherapy
m
and/or
preoperative radiation
• Complete planned chemotherapy regimen course
if not completed preoperatively plus endocrine
treatment if ER-positive and/or PR-positive (sequential
chemotherapy followed by endocrine therapy).
• Complete up to one year of HER2-targeted therapy
if HER2-positive (category 1). May be administered
concurrently with radiation therapy
n
and with
endocrine therapy if indicated.
Response
No response
See above pathway
Individualized treatment