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Outcome Assumptions from Our Historical Datasets

Year 1 Year 2 Year 3 Year 4 Year 5

Proportion Alive 2D

100.00% 70.00% 65.00% 60.00% 55.00%

Patients Alive 2D

1318 2240.6 3097.3 3888.1 4613

Proportion Alive 3D

100.00% 85.00% 75.00% 79.00% 65.00%

Patients Alive 3D

1318 2438.3 3426.8 4349.4 5206.1

Proportion with Toxicity

2D

0.00% 10.00% 20.00% 30.00% 30.00%

Patients with Toxicity 2D

0

131.8

395.4 790.8 1186.2

Proportion with Toxicity

3D

0.00% 1.00% 2.00% 3.00% 3.00%

Patients with Toxicity 3D

0

13.18

39.54 79.08 118.62

Working Patients 2D

1318 2108.8 2701.9 3097.3 3426.8

Working Patients 3D

1318 2425.12 3387.26 4270.32 5087.48

* Grade ≥ 3 toxicity : precludes normal work