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Is it important to reduce irradiated
volume?
Evidence that bowel irradiation is related with acute morbidity
Evidence that bowel irradiation is related with late morbidity
Randomised trials (Chopra et al (TMH) Klopp et al (MDACC)
Preliminary EMBRACE data
Chopra S, IJROBP, 88, 630-635, 2014
Late toxicity: diarrhea
IMRT
CRT