87 / 192
© 2012 AOAC INTERNATIONAL
AOAC O
FFICIAL
M
ETHODS
OF
A
NALYSIS
(2012)
G
UIDELINES
FOR
S
TANDARD
M
ETHOD
P
ERFORMANCE
R
EQUIREMENTS
Appendix F, p. 11
Figure A2. Relationship between LOD and LOQ. LOD is
defined as the lowest quantity of a substance that can be
distinguished from the absence of that substance (a blank
value) within a stated confidence limit. LOQ is the level above
which quantitative results may be obtained with a stated
degree of confidence.
Figure A1. Relationship between precision versus bias (trueness).
Trueness is reported as bias. Bias is defined as the difference
between the test results and an accepted reference value.
Figure A3. Horwitz Curve, illustrating the exponential
increase in the coefficient of variation as the concentration of
the analyte decreases [
J. AOAC Int
. 89, 1095(2006)].
AOAC OMB Meeting
February 10-11, 2016
80