121 / 671
(in months: 1= start, 2-25 are the months 1-24).
Opioid tolerance in advanced cancer patients:
a self limiting phenomenon?
661
412
210
162
118
101
65 58
39 30 26 20 16
13
14 9 10 9
7 6 5 5
3 2 4
0
100
200
300
400
500
600
700
1 2 3 4 5 6 7 8 9 10111213141516171819202122232425
number of patients
months
Physicians are (too) optimistic in
assessing prognosis / life expectancy
>13 weeks survival