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Conventional fractionation:

TD

50

in metastases patients < 46 Gy

TD

50

in primary liver cancer < 40 Gy

Dawson et al. IJROBP 53: 810; 2002

TD

50

in non-HBV carriers: 50 Gy

TD

50

in HBV carriers: 46 Gy

Cheng et al. IJROBP 60:1502; 2004

Dawson et al. 2002

Challenge I: Risk of morbidity (RILD)