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Transdermal fentanyl
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Fentanyl more potent than morphine;
equianalgesic dose 25
g/hr = 10-20mg 4 hourly
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Morphine required for breakthrough pain
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Controlled release formulation
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T½e is around 12 hours
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Absorption temperature dependent
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Side-effect profile similar to morphine
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Morphine
Fentanyl may cause withdrawal reaction in
10% …..? 24 hour overlap period required