SPIFAN Meeting (September 17, 2016)

Folate SMPR 2011.006

(approved April 5, 2011)

Applicability:

Determination of total folate [supplemental folic

acid or 5-methyl-tetrahydrofolate, and

endogenous 5-methyl-tetrahydrofolate

polyglutamate] in all forms (powders, ready-to-

feed liquids, and liquid concnetrates) of infant,

adult, and pediatric nutritional formula.

UPLC/MS/MS procedure

C-Folic Acid

(internal std)

Homogenize

Protease

Amylase

Buffer

& Heat

T. Gbatu, J. Szpylka, A. Gheney, AOAC Annual meeting 2008.

SPIFAN

Stakeholder

Panel

September

2010