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Based on experimental observations:
•
Traditional models for cell survival after radiation may
overestimate the cell kill (especially with high dose per
fraction)
•
In addition to direct radiation cell kill, there may be
indirect cell kill related to
–
Vascular effects and
–
Immune effects
•
Chemotherapy may enhance SBRT induced cell kill
•
Hypoxia should not be ignored; why not add nimorazole?