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Risk adapted fractionation – tumor location
Central location
Chang JTO 2015
• SBRT for central location - standard practice
(Roesch submitted)
• Optimal dose and definition of “too” central lacking
3 x 20 – 22Gy
~ 50% severe toxicity @ 2 years
5 x 10 – 12Gy
5 x 10-11Gy: 2 in 34 G3-5 Tox
5 x 11.5-12Gy: 13 in 86 G3-5 Tox
Timmerman JCO 2006
Bezjak IJROBP Supp 2015
13.06.2016
Matthias Guckenberger - ESTRO SBRT Course 2016 Athens
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