754 / 1224
/
No difference in oncological outcome
Smaller margins -> reduced toxicity
Stereotactic Radiotherapy / Matthias Guckenberger 13.06.2016
SBRT compared to MODERN CF-RT
Tx
Dose
Margin
SBRT
3 x 22Gy
5-10mm
CF-RT
35 x 2Gy
20mm
Tx
3a OS
FFP
Pneumonitis Esophagitis
SBRT
34%
61%
16%
9%
CF-RT
34%
57%
34%
32%
Randomized
SPACE
trial in 102 patients with stage I NSCLC
Nyman ESTRO 2014