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Dutch phase III trial: WBRT vs SBRT 4-10 leasions
Volume
Per protocol
D (Gy)
Acceptable variation
Unacceptable variation
PTV (largest leasion)
V100% = 99%
97%<V100%<99%
V100%<97%
PTV (other leasions)
V100% = 99%
97%<V100%<99%
V100%<97%
PTV (all leasions)
Dmax 140%
D2% =140%
D2% > 140%
OAR
D max per protocol (Gy)
Acceptable variation (Gy)
Unacceptable variation (Gy)
Brain stem
16
D 0.1cm3≤16
D 0.1cm3>16
Cochlea
12
D 0.1cm3≤12
D 0.1cm3>12
Chiasm
10
D 0.1cm3≤10
D 0.1cm3>10
Lens_L
5
D 0.1cm3≤10
D 0.1cm3>10
Lens_R
5
D 0.1cm3≤10
D 0.1cm3>10
Optic nerves
10
D 0.1cm3≤10
D 0.1cm3>10
Pituary gland
10
D 0.1cm3≤10
D 0.1cm3>10
0-2 mm CTV-PTV margin, 1-2 mm CT slice thickness