880 / 1224
/
Study
Patients
Toxicity
Hoyer 2005
Phase II
22
5 cases with severe GI tox
Koong 2005
Phase II
17
2/17 acute G3 GI
Schellenberg
2008
Phase II
16
Late:
5x G2 ulcers
1x G3 duodenal stenosis
1x G4 duodenal
perforation
Schellenberg
2011
Phase II
20
3x G2 ulcers
1x G4 duodenal
perforation
ESTRO SBRT Course 2015 - Emerging SBRT indications
11
SBRT for locally advanced pancreatic cancer
• (Very) high rates of GI toxicity DESPITE short FU
• Difficult (impossible) sparing of duodenum