1068 / 1726
Institutional series >100 patients ”radiographic-era”
Author (ref)
acrual period
No. patients, eligibility
Treatment
Vaginal
recurrence
Locoregional
recurrence
Survival
Severe complications
Sorbe et al.
35
404; Stage I
0,7% 3,0% 92% OS at 5-years 6.9% significant
publ 1990
MacLeod et al.
31
141; Stage I-IIIA 4 x 8.5 Gy at surface
1,4% 2,0% 91% OS at 5-years no grade 3/4
1985-1993
Weiss et al.
36
122; Stage I-II
3 x 7 Gy at surface
1,6% 4,1% 94% NED at 5-years no grade 3/4
1987-1993
Eltabbakh et al.
28
332; Stage IA grd 1-2 1 x 30 Gy LDR at surface 0,0% 0,6% 99% DFS at 5-years 2.1% grade 3/4
1958-1994
Petereit et al.
32
191; Stage IA grd 1-2 2 x 16.2 Gy at surface 0,0% 0,5% 95% OS at 5-years 0.5% grade 4
1989-1997
ovoids
Anderson et al.
26
102; Stage I
3 x 5 Gy at 0.5 cm 1,0% 1,9% 84% OS at 5-years no grade 3/4
1990-1996
Horowitz et al.
29
164; Stage I-II
3 x 7Gy at 0.5 cm
1,2% 0,6% 87% OS at 5-years no grade 3/4
1989-1999
Alektiar et al.
25
382; Stage I-II
3 x 7Gy at 0.5 cm
0,8% 0,0% 93% OS at 5-years 0.5% grd 3/0.3% grd 4
1987-2002
Solhjem et al.
33
100; Stage I grd 2-3 and3 x 7Gy at 0.5 cm
0,0% 0,0% 98% OS at 3-years no grade 3/4
1998-2004 IB grd 1-2 if >2cm
Ataham et al.
27
128; Stage I
5 x 5.5 Gy at 0.5 cm 0,0% 1,6% 96% OS at 5-years no grade 3/4
1994-2005
Institutional series including at least 100 patients
•
Different: dose/fractionation & prescription
•
Different applicators: most cylinder, but also ovoid, ring, mould