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Institutional series >100 patients ”radiographic-era”

Author (ref)

acrual period

No. patients, eligibility

Treatment

Vaginal

recurrence

Locoregional

recurrence

Survival

Severe complications

Sorbe et al.

35

404; Stage I

0,7% 3,0% 92% OS at 5-years 6.9% significant

publ 1990

MacLeod et al.

31

141; Stage I-IIIA 4 x 8.5 Gy at surface

1,4% 2,0% 91% OS at 5-years no grade 3/4

1985-1993

Weiss et al.

36

122; Stage I-II

3 x 7 Gy at surface

1,6% 4,1% 94% NED at 5-years no grade 3/4

1987-1993

Eltabbakh et al.

28

332; Stage IA grd 1-2 1 x 30 Gy LDR at surface 0,0% 0,6% 99% DFS at 5-years 2.1% grade 3/4

1958-1994

Petereit et al.

32

191; Stage IA grd 1-2 2 x 16.2 Gy at surface 0,0% 0,5% 95% OS at 5-years 0.5% grade 4

1989-1997

ovoids

Anderson et al.

26

102; Stage I

3 x 5 Gy at 0.5 cm 1,0% 1,9% 84% OS at 5-years no grade 3/4

1990-1996

Horowitz et al.

29

164; Stage I-II

3 x 7Gy at 0.5 cm

1,2% 0,6% 87% OS at 5-years no grade 3/4

1989-1999

Alektiar et al.

25

382; Stage I-II

3 x 7Gy at 0.5 cm

0,8% 0,0% 93% OS at 5-years 0.5% grd 3/0.3% grd 4

1987-2002

Solhjem et al.

33

100; Stage I grd 2-3 and3 x 7Gy at 0.5 cm

0,0% 0,0% 98% OS at 3-years no grade 3/4

1998-2004 IB grd 1-2 if >2cm

Ataham et al.

27

128; Stage I

5 x 5.5 Gy at 0.5 cm 0,0% 1,6% 96% OS at 5-years no grade 3/4

1994-2005

Institutional series including at least 100 patients

Different: dose/fractionation & prescription

Different applicators: most cylinder, but also ovoid, ring, mould