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Volume is important!
50
60
70
80
90
100
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120
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140
0 10 20 30 40 50 60 70 80 90 100 110
Volume HR CTV, cm
3
HR-CTV D90 optimized
Optimised
Violation of OAR constraint
Application of needles
11% needles
64% needles
K Tanderup et al, Radiother Oncol 2010