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Translating random uncertainties to EQD2: single fraction dose
Example HDR : HR CTV, variation 13% physical dose
-6.00
-4.00
-2.00
0.00
2.00
4.00
6.00
2.00 4.00 6.00 8.00 10.00 12.00 14.00
D90 [Gy]
observed variation in Gy
physical dose: 6.0, 7.0, 8.0 Gy
EQD2 (alpha/beta=10 Gy): 8.0, 9.9, 12.0 Gy
Example HDR : OAR, variation 22% physical dose
-6.00
-4.00
-2.00
0.00
2.00
4.00
6.00
2.00 4.00 6.00 8.00 10.00 12.00 14.00
D 2cm³ [Gy]
observed variation in Gy
physical dose: 4.4, 5.0, 6.3 Gy
EQD2 (alpha/beta=3 Gy): 6.5, 8.0, 11.7 Gy