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Translating random uncertainties to EQD2: single fraction dose

Example HDR : HR CTV, variation 13% physical dose

-6.00

-4.00

-2.00

0.00

2.00

4.00

6.00

2.00 4.00 6.00 8.00 10.00 12.00 14.00

D

90

[Gy]

observed variation in Gy

physical dose: 6.0, 7.0, 8.0 Gy

EQD2 (alpha/beta=10 Gy): 8.0, 9.9, 12.0 Gy

Example HDR : OAR, variation 22% physical dose

-6.00

-4.00

-2.00

0.00

2.00

4.00

6.00

2.00

4.00

6.00

8.00 10.00 12.00 14.00

D

2cm³

[Gy]

observed variation in Gy

physical dose: 4.4, 5.0, 6.3 Gy

EQD2 (alpha/beta=3 Gy): 6.5, 8.0, 11.7 Gy