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N= 115

BT

EBRT

stage IB2 - IVA

Volume change during treatment

V

2

V

3

V

4

V

1

PV = 100 %

PV = 87 %

PV = 40 %

PV = 31 %

0

20

40

60

80

100

1

2

3

4

Proportional Volume [%}

•Rapid response: 2.2% / Gy

•Steep slope

•Low AUC (24 %)

•Slow response: 0.8% / Gy

•Low slope

•High AUC (50 %)

Alive & well

at 7 y

LR at 1 y

Death at 2 y

Regression to

P

roportional

V

olume:

PV = V

x

/ V

1

[%]

S

ize of the tumor at Brachytherapy

Mayr NA, et al. Int J Radiat Oncol Biol Phys 2010