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Taylor A et al., IJROBP 2005

Ultrasmall Particles of Iron Oxide (USPIO) data

Taylor A, Rockal AG, Reznek RH et al. Mapping pelvic lymph nodes: guidelines for delineation in intensity-

modulated radiotherapy. Int. J. Radiation Oncology Biol. Phys., Vol 63.no.5, 1604-1612, 2005.

20 patients, gynae cancer

USPIO administered

All nodes outlined

61 nodes / patient

1 to 12 mm short axis

Muscle and bone excluded

3D margin around vessels (mm

)

3

5

7

10

15

Nodal coverage

56 %

76 %

88 %

94 % 99 %

Bowel V in PTV

-

-

147 cm

3

190 cm

3

266 cm

3

7 mm margin with minor adjustments: 99 % coverage of lymph nodes

Nodal CTV

(

CTV-E

)