241
Disorders of
White Blood
Cells and
Lymphoid
Tissues
he hematopoietic system and lymphoid tissues are
responsible for the generation and regulation of
the blood cells that function in the transport of oxy-
gen, defense against microorganisms, and preservation
of the integrity of the vascular system. This chapter is
divided into two parts: the first provides an introduction
to the hematopoietic system, lymphoid tissues, and the
white blood cells; and the second focuses on disorders of
the white blood cells, including those of nonneoplastic
(neutropenia and infectious mononucleosis) and neo-
plastic (lymphomas, leukemias, and multiple myeloma)
origin. The megakaryocytes and platelets are discussed
in Chapter 12, the red blood cells in Chapter 13, and
the immune system (lymphocytes and monocytes) in
Chapter 15.
Hematopoietic and
LymphoidTissues
Blood consists of blood cells (i.e., leukocytes or white
blood cells, thrombocytes or platelets, and erythrocytes
or red blood cells) and the plasma in which the cells are
suspended. These cells all derive from a single pool of
pluripotent stem cells in the bone marrow, which give rise
T
Hematopoietic and Lymphoid Tissues
The Bone Marrow and Hematopoiesis
Hematopoietic Growth Factors
Leukocytes (White Blood Cells)
Granulocytes
Agranulocytes
Leukocyte Developmental Stages
Lymphoid Tissues
Nonneoplastic Disorders of White Blood Cells
Neutropenia (Agranulocytosis)
Pathogenesis
Clinical Course
Infectious Mononucleosis
Pathogenesis
Clinical Course
Neoplastic Disorders of Hematopoietic
and Lymphoid Origin
Leukemias
Classification
Etiology and Molecular Biology
Acute Leukemias
Chronic Leukemias
Malignant Lymphomas
Non-Hodgkin Lymphomas
Hodgkin Lymphoma
Plasma Cell Dyscrasias
Multiple Myeloma
3
Hematopoietic
Function
11
C h a p t e r
U N I T
