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Oropharyngeal Cancer and Human Papilloma Virus
•
HPV-DNA detected in 15-62% HNSCC, higher in
oropharynx
•
Patients with HPV +ve oropharyngeal canrcinoma
- Typically younger
- Non-smokers and Non-drinkers
- LN mets have a firm rather than hard consistency
- Tumour shows basaloid features
- +ve for p16 on immunohistochemical staining
- Outcome is
better
than non-HPV related carcinomas
Rischin D, Young RJ et al. J Clin Oncol. 2010 Sep 20;28(27):4142-8.