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5

Docket No. 50229-337, filed as a US Provisional Patent Application, No. 60, XXX,

XXX, July 23

rd

, 2003.

3. Stinchcomb, Audra; Crook, Peter

; Hamad, Mohamed

. Enhancing transdermal

delivery of opiate antagonsts and agonists using codrugs linked to bupropion and

hydroxybupropion. UK Disclosure No. 1426, July 253

th

, 2006.

PUBLICATIONS:

4. Kiptoo, Paul K.; Paudel, Kalpana S.; Hammell, Dana C.;

Hamad, Mohamed O

.; ; Crooks,

Peter A. Stinchcomb, Audra L. In vivo evaluation of transdermal codrug of 6-

β

-naltrexol

linked to hydroxybupropion in hairless guinea pigs. Eur. J. Pharm. Sc. 2008 April, 33(4-

5), 371379

5.

Hamad, Mohamed O

.; Kiptoo, Paul K.; Stinchcomb, Audra L.; Crooks, Peter A.

Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6-

β

-

naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents.

Bioorganic & Medicinal Chemistry, 2006, 14(20), 7051-7061.

6. Kiptoo, Paul K.;

Hamad, Mohamed O

.; Crooks, Peter A.; Stinchcomb, Audra L.

Enhancement of transdermal delivery of 6-

β

-naltrexol via a codrug linked to

hydroxybupropion. Journal of Controlled Release, 2006, 13(2), 137-145.

7. Valiveti, Satyanarayana; Paudel, Kalpana S.; Hammell, Dana C

.; Hamad, Mohamed O

.;

Chen, Jianhong; Crooks, Peter A.; Stinchcomb, Audra L. In vitro/in vivo correlation of

transdermal naltrexone prodrugs in hairless guinea pigs. Pharmaceutical Research,

2005, 22(6), 981-989.

8. Paudel Kalpana S; Nalluri Buchi N; Hammell Dana C; Valiveti Satyanarayana;

Kiptoo Paul;

Hamad Mohamed O

; Crooks Peter A; Stinchcomb Audra L

Transdermal delivery of naltrexone and its active metabolite 6-

β

-naltrexol in

human skin in vitro and guinea pigs in vivo. Journal of Pharmaceutical Sciences,

2005, 94(9), 1965-1975.

9. Vaddi, Haranath K.;

Hamad, Mohamed O

.; Chen, Jianhong; Banks, Stan L.; Crooks,

Peter A.; Stinchcomb, Audra L. Human skin permeation of branched chain 3-O-alkyl-ester

and carbonate prodrugs of naltrexone. Pharmaceutical Research, 2005, 22(5), 758-765.

10. Hammell, D.C.; Stolarczyk, E.I.; Klausner, M.;

Hamad, M.O

.; Crooks, P.A.; Stinchcomb,

A.L. Bioconversion of naltrexone and its 3-O-alkyl-ester prodrugs in a human skin

equivalent. Journal of pharmaceutical sciences, 2005, 94(4), 828-836.

11. Satyanarayana Valiveti , Audra L. Stinchcomb, Dana C. Hammell, Kalpana S.

Paudel, ,

Mohamed Hamad

, Peter A. Crooks, , Audra L. Stinchcomb. In vivo

evaluation of 3-O-alkyl-ester transdermal prodrugs of naltrexone in hairless

guinea pigs. Journal of Controlled Release, 2005, 102(2):509-520.

12. Pillai, Omathanu;

Hamad, Mohamed

; Crooks, peter; Stinchcomb, Audra.

Physicochemical evaluation, in vitro human skin diffusion and concurrent

OMB Meeting Book

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March 2, 2017