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First line

Doublets or triplets?

Triplets only in patients with

high symptom burden

Stop using epirubicin

Ramucirumab-paclitaxel

Second line

What should be a standard?

Work in progress

PS 0-1; PFS > 3-6 months

Molecular classification

Do we have distinct treatment choices for

these different molecular pathways?

How can we address tumor heterogenity

when we design GC clinical trials?

Are all patients candidated to a second line therapy?

Methodological framework

Innovative clinical trial designs

03/28/2017